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‘Freckles’ on his retina prompts a man to get himself tested for colon cancer | Above a composite drawing showing a close-up image of a freckle CHRPE on the retina of a patient with colon polyp syndrome. CHRPE has a “statistically significant” correlation with hereditary colon polyps known as familial adenomatous polyposis, or FAP. It may be that the freckles are caused by the same genetic mutation that produces the polyps.
July 19, 2013: Familial Adenomatous Polyposis: Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when left untreated. From early adolescence and onwards, patients with this condition develop hundreds to thousands of polyps. These may bleed, leading to blood in the stool.