Leukocytes have different features that can help differentiate them from one another (especially when stained). Neutrophils have 3-5 –lobed nuclei and violet granules. Eosinophils have 2 large connected lobes and orange-stained granules. Basophils’ nuclei are difficult to see due to dark, coarse granules. Lymphocytes have large, round nuclei that nearly fills the cell. Monocytes have U or kidney shaped nuclei and are often large in size.