The next generation of super heavy-lift launch vehicle is the privately developed SpaceX Falcon Heavy. Although NASA's Saturn V moon rocket could lift about two and a half times as much mass, the Falcon Heavy would still be the most powerful U.S. rocket to be launched since the Saturns were retired in 1972. [See it here.]
From NASA’s Archives, 50 Amazing Photos Of The Apollo Moon Missions
A return to deep space-Today's flight, called Exploration Flight Test-1, marks the first time a spacecraft built for humans has traveled out of low-Earth orbit since Apollo 17 launched to the moon in 1972. Diagrams show first flight test of Orion capsule.