Pok Jl 1802. Dr. Samuel H. P. Lee's Bilious Pills for Yellow Fever is one of the first highly successful patent medicines of the Hudson Valley. Dr. Lee lived in New London, Connecticut. At the time of its first marketing, yellow fever had struck New York several times and was beginning to impact the Hudson Valley each time it returned. Local physician James Van Kleeck sold it out of his apothecary in Poughkeepsie, and was the region's local distributor for this remedy.