DIY hyaluroic serum Weigh out Hyaluronic Acid powder. Pour 60mL of distilled water into a plastic bottle. Add the Hyaluronic Acid to the distilled water, close the cap.. SHAKE THE CRAP OUT OF IT. You will get globs and bits and undissolved powder even after shaking- this is normal. Leave it in fridge. it will generally fully dissolve into a homogenous gel within about 1-2 hrs anyway.