Sarah Feeny (Ampersand)

Sarah Feeny (Ampersand)

Sarah Feeny (Ampersand)
More ideas from Sarah Feeny
Functions of T cells in asthma: more than just TH2 cells

Functions of T cells in asthma: more than just TH2 cells

So have you ever heard of Rheumatoid Arthritis? If so, how much do you think you really know about this disease? Well, this infographic provides some really good information on this chronic autoimmune condition.

So have you ever heard of Rheumatoid Arthritis? If so, how much do you think you really know about this disease? Well, this infographic provides some really good information on this chronic autoimmune condition.

Breakthrough designation explained [infographic] via @Genevieve Roy #hcmktg

Breakthrough designation explained [infographic] via @Genevieve Roy #hcmktg

Figure 3. Monoclonal antibody therapeutic targets in MS. This is a schematic of an intracranial blood vessel penetrating the CNS parenchyma. The blood vessel, or peripheral compartment, contains the most of the targets for the currently available immunomodulatory monoclonal antibody therapies in MS. Natalizumab blocks VLA-4 (or α4β1 integrin) receptors on B or T lymphocytes, preventing them from interacting with VCAM and crossing the BBB into the CNS. Anti-CD20 antibodies (rituximab…

Figure 3. Monoclonal antibody therapeutic targets in MS. This is a schematic of an intracranial blood vessel penetrating the CNS parenchyma. The blood vessel, or peripheral compartment, contains the most of the targets for the currently available immunomodulatory monoclonal antibody therapies in MS. Natalizumab blocks VLA-4 (or α4β1 integrin) receptors on B or T lymphocytes, preventing them from interacting with VCAM and crossing the BBB into the CNS. Anti-CD20 antibodies (rituximab…

Figure 1. Mediators of MS pathogenesis that are targets of or regulated by monoclonal therapy. The T-cell lineage is comprised of CD8+ cytotoxic T cells, as well as CD4+ T cells that can be further divided into Th1, Th17, Th2, and Treg lineages. The cytokines required for stimulation of these lineage are noted from arrows deriving from the naïve T cell, and many of the critical downstream cytokines released by each T-cell type are depicted. The B-cell lineage is comprised of cells that…

Figure 1. Mediators of MS pathogenesis that are targets of or regulated by monoclonal therapy. The T-cell lineage is comprised of CD8+ cytotoxic T cells, as well as CD4+ T cells that can be further divided into Th1, Th17, Th2, and Treg lineages. The cytokines required for stimulation of these lineage are noted from arrows deriving from the naïve T cell, and many of the critical downstream cytokines released by each T-cell type are depicted. The B-cell lineage is comprised of cells that…

The role of PD-L1 in the local tumor microenvironment

The role of PD-L1 in the local tumor microenvironment